There is very little "mysticism" or "myth" in magick unless you want to incorporate it. Think more in terms of mind over matter and focus on strengthening and controling your mind and emotions to create a stronger sense of self and positivity about you. That in itself is magick. Magick is about turning within to change that which is around us and to gain a deeper understanding of ourselves, people, and nature. Very few scientists are athiests. Why? Because in studying science, the intricacy of the world and how things work is so amazing, it couldn't have been created by randomness. Most scientists believe in intelligent design due to the complexity of our world.
There is so much to this world that is beyond our sight/grasp, for example http://www.msnbc.msn.com/id/13070896/ns/technology_and_science-science/t/physicists-probe-fifth-dimension/
that magick isn't that far fetched, nor are spirits when one understands that the world is far vaster than we could ever imagine. I personally believe that magick has utilized this without every truly knowing why it works, just knowing it does. Just like ancients believed a higher being dragged the sun across the sky, it doesn't mean the sun didn't travel across the sky, but the "why" changed as we learned and explored. In a few hundred years, we may understand fully why magick works. But in my mind, based off of my own experience and seeing that magick has been used over the entire world in similar ways, even within cultures that never once contacted each other, and they knew it worked, and how to make it work. It's obvious to me that it is very real, just not entirely understood. We try to place logic and reasoning on things we do not fully understand, it is within our natures to think we know the answers. But the evidence that it exists is there, we just can't touch it or see it in a scientific way....yet.