Pics or it didn't happen.
For a physical change to occur, yes your whole skeleton would become messed up, deformed, and your skin would probably tear too. Notice my use of the conditional tense, implying that under certain conditions that this is possible this would happen. But it isn't anything physical.
The closest thing we have to werewolves would perhaps be Wendigo Syndrome (a syndrome in which you crave human flesh, developed almost exclusively among Native Americans) or skinwalkers. I do believe in skinwalkers, but not werewolves (though I do want to see that new Benicio Deltoro movie!).
And let's not forget hypertrichosis.