I keep the card separate from the spread and use the card as extra clue once I have done the reading and interpreted how all of the cards ,within the spread relate between each other.I see it rather as source of extra insight ,and I decide how this insight fits into the situation ,depicted by the cards I picked for the spread.
This is of course my way to go about with it.Many people simply put the card back in the deck and keep shuffling or some use it as their first chosen card in position one.
I adopted this method that I am using till this day ,because that is how it felt right to me and I tend to listen to my intuition in general.
I think the best way to go is to ask your intuition, about what should you choose to do with it.Of course hearing other people opinions is not bad as idea either.
Read what everyone has to say ,then consult your intuition and only then go about choosing your way to go about with it in the future .
Best of luck.:)